Physiology Insulin Resistant or Hidden Glycation on Keto Way of Eating (Keto-WOE)
As my experience of being a Naturopath & Keto-Dietician, I see many of my clients experiencing a fasting blood glucose elevation phenomenon over applying my Keto-Protocol for therapeutic purpose, which also apply Intermittent Fasting (IF) and sometimes I would suggest a Prolonged Fasting (PF) for the advance level.
Some people may call this “Physiology Insulin Resistant” which happen during adaptation into a Low Carb High Fat (LCHF) diet like Keto. But the truth is there is no Physiology Insulin Resistant. What really happen during initiating my Keto-Protocols was the fasting and the high fat ratio macros that maintain the low insulin & low IGF-1 (from low protein) on the Induction Phase was creating an “Autophagy” effect, which clearing their previous “Hidden Glycation” and this transition process elevate their previous average fasting blood glucose (from the previous standard diet). This process will take time around a week or a month (sometimes up to 2 month) depending how severe the glycation was within my clients body. The rise in the fasting blood glucose was seen on the 2nd to 4th day within the Induction Phase initiation, and this will tell the clients (even with previous normal Fasting Blood Glucose on Standard Diet) about the real problem behind their health issues which is the “Metabolic Disorder”.
This phenomenon is not just happen to my clients with their existing health issues, but also happen to many fellow-ketoers that think they didn’t have any sort of health issues from their previous Standard Diet (High Carb Low Fat). Also for some fellow-ketoers that have been doing Keto or Low Carb for years, my Keto-Protocols seems to jump start their ketosis level and reveal this phenomenon too for ketoers that do have unresolved insulin resistant (from having high protein macro on their keto-macros plan)
Glycation is a process in which excess sugar in the bloodstream “sticks” to the proteins from which our cells and body tissues are made.
Over time, these glycated tissues develop structures which become “advanced glycation end products” or “AGEs”. The glycated end products inhibit the functions of the proteins to which they are attached, and the proteins become damaged and unable to perform or communicate as needed. For example, loss of vision, nerve damages, atherosclerosis and other complications of diabetes are a result of glycation damage to the various proteins which are critical for the function of the eyes, nerves and arteries.
A simple analogy of glycation would be the consequences of pouring maple syrup all over your computer keyboard, and then trying to use it.
Glycation increases as concentrations of blood sugar increase. A high consumption of fructose seems to worsen glycation as well. Fructose accelerates glycation within the body at a rate 10 times faster than simple blood glucose. And worse, that even a single incident of higher post prandial glucose levels (after meal blood sugars) is associated with the formation of AGE precursors.
Glycation can be measured from the HbA1C test, but this not always be the criteria of having insulin resistant. This is because glycation can affect many cells within the body beside the haemoglobin, such as endothelial cells, smooth muscles, cells of the immune system from tissue such as lung, liver, and kidney. And also the haemoglobin has turn over period of 120 days which supposed to be cleared when we have already doing the Keto-WOE for at least 4 months.
Glycation that affect long-lived cells (such as nerves and different types of brain cell), long-lasting proteins (such as crystallins of the lens and cornea), and DNA may accumulate substantial damage over time. Cells such as the retina cells in the eyes, and beta cells (insulin-producing) in the pancreas are also at high risk of damage from this glycation.
Several methods are available for the measurement of AGEs. Circulating or tissue-bound AGEs can be measured by enzyme-linked immunosorbent assays (ELISA) using monoclonal or polyclonal antibodies, fluorescence spectroscopy using the fluorescence properties of some AGEs, or high-performance liquid chromatography (HPLC) and mass spectrometry (MS), with the later method being probably the most reliable. MS-based methods allow, for example, for measurements of the AGEs’ representative carboxymethyllysine (CML) in the urine by combining isotope dilution and gas chromatography (GC)–MS analysis. This method is sensitive, reproducible, accurate, rather cheap and therefore often used in laboratories for the diagnosis and monitoring of age-related chronic diseases
My Keto-Protocol with high fat ratio macro (75% – 80% from total calories) will induce a prolonged low insulin state & low IGF-1 from the fasting hours, that will clear this “Glycation” by initiating a natural selection of cellular compatibility that make every cells within the body to must be efficient & healthy enough to survive the very low glucose availibilty on the blood serum plasma.
Fat is my Keto-Protocol’s primary macronutrient, supplying around 75% – 80% of total calories. This is based on the premise that fat is:
• the body’s preferred fuel.
• supportive of a lean physique.
• very satiating, making it protective against cravings for unhealthy foods.
• the single macronutrient least likely to suppress the life-extending, age-inhibiting expression of our most longevity-oriented genes.
A critical feature of my Keto-Protocol is that we consume no more protein than is necessary (15% – 20% from total calories at my Keto-Protocol), which is where most low-carb dieters & fellow ketoers mess up. This is because excess protein:
• raises insulin, leptin, IGF-1, and the mTOR pathway, each of which is suspected to blunt the expression of our most longevity-oriented genes.
• is burned as fuel (as sugar), with unwanted byproducts and side-effects.
• inhibits the intracellular recycling mechanism of autophagy.
And the “Key Ingredient” (the whole idea) of my Keto-Protocol is the Fasting it self. Keto was invented and designed to mimic the “Fasting Condition” in the first place, but nowadays I see many modification from the first invented classic standard ketogenic diet which was the most powerful one for its therapeutic effect and fat loss / weight loss effect. It was also the closest Keto-Macros plan that can duplicate the body hormonal and cellular adaptation just like during the real fasting condition.
So my Keto-Protocol was actually designed to make ones to be able to adapt better to fasting conditions, which is the fasting itself that will give the most benefit over wellness & longevity, that also result in a lower body fat from being “healed & healthy”.
Autophagy is the main purpose of why fasting is more important than the Keto itself. Because this process can only be efficient and effective during a very low insulin state which resulted from resting the digestion and spares more energy for the Autophagy process.
Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins (clearing the glycation), clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens.
The bottom line here is that reducing your blood sugar by using fasting and high fat ratio keto-macros plan will reduces blood insulin levels, glycation end products, and inflammation. These three factors are closely associated with higher mortality rates from all sorts of diseases and also give you a faster result for an aesthetic purposes (low body fat)
And the key to achieve this benefits is by mastering the fasting using the right keto-macros ratio and also trusting the body for its satiety response that occur during eating, which is not trying to hit the macros plan on the eating window on my Keto-Protocol, when the satiety has kick-in.
I also advise to anyone that would care to try my Keto-Protocol to extend their fasting hours earlier (16 hours at the initial) when they feel they were able to do so (for instance, adding 1 to 2 more fasting hours), by trusting the body (brain) when there’s no hunger occur even when the eating windows has arrived. This way ones can master the fasting faster and also accellerate the adaptation to a new fasting blood glucose equilibrium that was aim to be below 80 mg/dL (4,4 mMol) on my Keto-Protocol
Please refer to this post link to see my Keto-Protocol :
And these are a good reading for you that interesting to find out more about “Glycation” over your previous years of exposure to high carbs laden foods in the past.
God Bless You for Finding Fasting & Keto as Your Way of Life Now